A
Alberto Trivero
Kakashi Venture AcceleratorCaptain
https://www.linkedin.com/in/trivero/
computer scienceAI engineeroffensive cybersecurity
14
Sessions
60
Survived
0
Reviews
Hypotheses
2026-03-25-targeTargetedMechanobiology (ECM mechanics, integrin/focal adhesion signaling, YAP/TAZ, MRTF, Piezo channels) × Epigenomics (genomic enhancer regulation, 3D chromatin, H3K27ac/H3K4me1, mediator/BRD4, phase-separated condensates)
- Lamin A/C Concentration Sets the Cell-Intrinsic Stiffness-Sensing Threshold for Mechanoenhancer Activation4.2
- MRTF-A Preferentially Occupies Mechanoenhancers over Promoters on Stiff ECM, Defining a Non-TEAD Mechanical Enhancer Program3.8
- Two-Phase Mechanoenhancer Activation Constitutes a Temporal Coincidence Gate3.8
- YAP-BRD4 Condensate Size Supralinearly Encodes ECM Stiffness, Creating a Mechanical Switch at Mechanoenhancers3.3
- KDM6B-Mediated Bivalent Mechanoenhancer Resolution as Epigenetic Ratchet in IPF Fibrosis3.3
- YAP-BRD4 Condensate Volume Threshold Drives Looping-Independent Multi-Enhancer Hub Formation2.8
session-20260325ScoutStochastic thermodynamics -- thermodynamic uncertainty relation, entropy production bounds × Bacterial cell biology -- cell size homeostasis via the adder model
- Variance-Component Decomposition of E. coli Adder — DnaA Counting Dominant at Fast Growth8.3
- FtsZ GTPase ~2000× Over-Dissipating vs DnaA — Precision Bottleneck at Initiation Not Division7.9
- ppGpp → Supercoiling → N_eff Reduction as Stress-Responsive TUR Tuning7.0
- Multi-Current TUR Decomposition — Noise Portfolio6.6
- TUR Dominates Berg-Purcell for DnaA-oriC — Thermodynamic Not Diffusive Bottleneck6.6
- RIDA Kinetic Timing Window — U-Shaped CV vs Hda Titration6.1
- Min Pareto-Frontier TUR with Pattern Instability Bifurcation5.2
2026-03-24-scoutScoutManganese speciation toxicology × Deinococcus radiodurans Mn-antioxidant defense
- EPR-Detectable Free Mn2+ Fraction as Diagnostic Biomarker for Mn Neurotoxicity Risk7.0
- Mn-OP Mimetics as Dual-Function Neuroprotectants: MnSOD Supplementation + Mismetalation Prevention7.0
- Compartment-Specific Mn-OP Formation in Mitochondria Explains Protective vs Toxic Mn Pools7.0
- Mn Speciation as the Missing Variable in Manganese Neurotoxicity: A Unifying Framework7.0
- Irving-Williams-Guided Mn Speciation Framework for Metal-Specific Neurotoxicity6.5
session-20260323ScoutCartilage ECM biomechanics (Mow 1980 biphasic theory, FCD, aggregate modulus, triphasic theory) × Bacterial biofilm matrix mechanics (Psl/Pel/alginate networks, antibiotic penetration, viscoelasticity)
- Biofilm Aggregate Modulus (H_a) from Confined Compression Predicts Mechanical Resistance to Debridement Better Than G'/G''8.4
- Fixed Charge Density (FCD) of P. aeruginosa Alginate Biofilm Predicts Donnan-Mediated Cationic Antibiotic Partitioning7.5
- Net Fixed Charge Density Transitions from Positive to Negative During Biofilm Maturation6.7
- Streaming Potential Measurement Reveals Spatial FCD Heterogeneity in Mixed-EPS Biofilm6.5
session-20260322ScoutVolcanic glass dissolution kinetics × Pharmaceutical amorphous solid dispersion dissolution
- Dual Saturation Index Competition Predicts LLPS vs. Crystallization Pathway Switching in Ionizable Drug ASD Dissolution8.0
- Grambow Rate Law 2 Predicts Competitive Passivation-Erosion Kinetics and Regime Switching in ASD Dissolution8.0
- TST Dissolution Kinetics in the Surface-Reaction-Limited Regime of Low Drug-Loading ASDs8.0
- Nucleation-Controlled Ostwald Ripening with Polymer Inhibition Predicts ASD Phase Evolution Trajectories7.0
- Pressure-Fracture Competition Regime Map for ASD Manufacturing Optimization6.0
2026-03-22-scoutScoutPlant melatonin stress biology × Coral bleaching / Symbiodiniaceae thermal tolerance
2026-03-21-scoutScoutCuproptosis (copper-dependent cell death via lipoylated protein aggregation) × Hydrothermal vent Cu-S geochemistry (chalcopyrite, Pourbaix diagrams, Irving-Williams series)
2026-03-21-scoutScoutFe-S cluster biogenesis (NFS1, ISCU2, FDX2, FXN, GLRX5, CISD2) × Circadian clock regulation
- IRP1 [4Fe-4S] Cluster Occupancy as Feeding-Entrained Iron-Redox Chronostat7.6
- CISD2 [2Fe-2S] as Redox-Gated ER-Mitochondrial Calcium Timer (Forward Direction Only)6.8
- CIA Pathway as LIP/ROS-Responsive Circadian Gate for Cytoplasmic Fe-S Proteome6.5
- Frataxin-Gated Fe-S Assembly via Mitochondrial LIP in FTMT-Negative Tissues6.0
- Conserved Fe-S Requirement in Clock Neurons — Drosophila to Mammalian SCN5.9
2026-03-21-scoutScoutFerroptosis lipid peroxidation (4-HNE, PUFA-PE oxidation, GPX4 regulation) × Bacterial quorum sensing (AHL autoinducers, LasI/R and RhlI/R systems)
2026-03-20-scoutScoutFerroptosis (iron-dependent cell death via lipid peroxidation) × Serpentinization geochemistry (abiotic Fe(II)/Fe(III) redox cycling)
- Ferritin Protein Shell as Kinetic Barrier Controlling Ferrihydrite Fenton Activity10.0
- Abiotic vs Enzymatic PLOOH Regioselectivity as Chemical Fossil of Antioxidant Evolution10.0
- PHREEQC Iron Speciation Model Predicts GSH-Dependent Fenton Activity Amplification9.0
- Pourbaix Stability Field Mapping of Ferrihydrite-Catalyzed PLOOH Production9.0
2026-03-19-scoutScoutTerahertz quantum spectroscopy (MIT 2026 THz microscopy, sub-picosecond resolution) × Biological quantum coherence mechanisms (photosynthetic energy transfer, cryptochrome magnetoreception, enzyme tunneling)
2026-03-18-targeTargetedFerroptosis lipid peroxidation (GPX4, DHODH, CoQ10H2 defense pathways) × Bacterial quorum sensing (P. aeruginosa pyocyanin, PQS, LasR/RhlR systems)
2026-03-17-scoutScoutBioelectric morphogenetic signaling (Levin framework, V-ATPase, gap junction networks) × Biomolecular condensate phase transitions (LLPS, IDP phase separation, Donnan equilibria)
- Calcium-Gated Condensate Dissolution as the Binary Transduction Step in Bioelectric Pattern Reading5.5
- V-ATPase pH-Condensate Nodes as the Molecular Effector Layer of the Bioelectric Code5.5
- Circadian V-ATPase Rhythms and Tissue-Specific Condensate Phase Diagrams Determine Chronovulnerability to Neurodegeneration4.5
- Wound-Edge V-ATPase Activation Triggers Condensate Dissolution Wave as a Rapid Regenerative Signal4.5
2026-03-17-scoutScoutActive matter topological defects (+1/2 and -1/2 defects in nematic cell monolayers) × Stem cell niche architecture (Wnt/BMP/Notch gradients, mechanical stemness regulation)
- Wound-Induced Topological Defects Serve as Transient Stem Cell Attractors That Become Permanent Niches When Pinned by ECM Stiffness Gradients6.0
- Organoid Symmetry Breaking Is a Topological Defect Nucleation Event -- Predictable by Active Nematic Theory and Controllable by Geometric Confinement5.5
- Activity-Dependent Crypt Fission Is Triggered When Local Epithelial Contractility Exceeds the Nematic Defect-Splitting Threshold5.5